Job Description
Position Objective: Provide services as a Biologist in support of the overall functions of the Vaccine Production Program (VPP), Vaccine Research Center (VRC) within the National Institute of Allergy and Infectious Diseases (NIAID).
Duties and Responsibilities: - Develop downstream (purification) processes for recombinant proteins, virus vaccines, virus-like particles (VLP) and nucleic acids, that may be used as clinical candidates.
- Work collaboratively within the purification group to design, develop and optimize chromatography and filtration step (Normal Flow Filtration and Tangential Flow Filtration) unit operations to support process development of clinical trial vaccine candidates and mAb products.
- Purify research-phase recombinant proteins, virus vaccines, virus-like particles and/or nucleic acids in support of other groups or external collaborators.
- Work to prepare necessary materials (buffers, packed columns, etc.) in support of downstream process activities.
- Support technology transfer of processes to Lab's Pilot Plant for manufacture of clinical product through document generation and on-site support.
- Write and review technical protocols, reports and technology transfer documents.
- Analyze and compile data, present at various group/department meetings.
- Work collaboratively to design, run and analyze high throughput screens using TECAN automated bioprocessing system.
- Perform In vitro Transcription (IVT) and mRNA purification at multiple scales.
- Design and execute day to day development operations with minimal supervision.
Basic Qualifications: - Bachelor's degree in Bioengineering, Chemical Engineering, Biochemistry, or a related discipline.
- Minimum of two to five (2-5) years of experience in recombinant protein, pDNA, and mRNA purification development for GMP clinical-phase products.
- Experience with In vitro Transcription (IVT) and mRNA purification.
- Experience using high-throughput bioprocessing systems such as TECAN.
- Familiarity with computer software including word processing and data evaluation.
Minimum Qualifications: - Demonstrated knowledge of maintaining accurate and detailed records.
- Must be a team player who can effectively work with members from cross-functional departments.
- Strong oral and written communication skills.
- Ability to communicate effectively, orally and in writing, with non-technical and technical staff.
- Detail-oriented and possess strong organizational skills with the ability to prioritize multiple tasks and projects
*This is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required by this position.
To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
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Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability, protected veteran status or other characteristics protected by law.
Job Tags
Full time,